Aquaporin-4–positive myelitis associated with Sjögren syndrome and colonic adenocarcinoma
نویسندگان
چکیده
Neuromyelitis optica (NMO) is an inflammatory disorder of the CNS with prominent involvement of the optic nerve and the spinal cord. An autoantibody against aquaporin-4 (AQP4), a water channel abundant on astrocytic foot processes, is the biomarker of the disease. The term neuromyelitis optica spectrum disorders (NMOSD) includes AQP4-IgG-positive syndromes that may only partially fulfill contemporary criteria for diagnosis of NMO. NMOSD are frequently associated with other autoimmune disorders and there are increasing reports of NMOSD in patients with cancer.
منابع مشابه
Neuromyelitis optica spectrum disorder and Sjögren syndrome are overlapping disorders and participate in the same autoimmunity context?
Correspondence: Maria Lucia Vellutini Pimentel; Rua Garcia D’Avila, 64 sala 205; 22421-010 Rio de Janeiro RJ, Brasil; E-mail: [email protected] Conflict of interest: There is no conflict of interest to declare. Received 09 June 2014 Accepted 27 June 2014 Neuromyelitis optica (NMO), an idiopathic inflammatory demyelinating disease of the central nervous system that mainly affects the optic n...
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IMPORTANCE Chronic, intractable neuropathic pain is a common and debilitating consequence of neuromyelitis optica spectrum disorder (NMOSD) myelitis, with no satisfactory treatment; few studies have yet to explore its aetiology. OBJECTIVE To establish if myelitis-associated chronic pain in NMOSD is related to the craniocaudal location of spinal cord lesions. METHOD (1) Retrospective cohort ...
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